Mid-Term Meta-Analysis Results of Carotid Artery Stenting and Carotid Endarterectomy Based on Randomized Controlled Studies

Objective: A comprehensive of published randomized controlled trials (RCTs) was performed to evaluate the mid-term safety carotid artery stenting (CAS) versus endarterectomy (CEA) for both asymptomatic and stenosis. Material Methods: In this research, trails from 1994 until December 31, 2021 using ScienceDirect, Pubmed, Web Science, Sage, Ebscohost, Scopus Cochrane Central electronic databases. Major end points (any stroke, myocardial infarction, all-cause mortality) were extracted publications. We calculated pooled risk ratios (RRs) 95% confidence intervals (CIs) a fixed-effects model. The Q I2 statistic used as measure heterogeneity. Results: Twelve involving 8,301 (4,498 with CAS; 3,803 CEA) patients included in meta-analysis. When compared CAE, associated significantly increased any stroke (RR=1.397; CI: 1.159-1.684; p<0,001) but decreased infarction (RR=0,487; CIs: 0.302-0.786; p=0,003). No difference found allcause mortality (RR=1,009; 0.904-1.126; p=0,869) between 2 interventions, yet minor trend toward superiority favoring CEA. evidence significant heterogeneity analysis. Conclusion: CAE be superior term whereas CAS lower infarction. But robust results, further studies are needed address relative effectiveness future.